Karlheinz hat geschrieben:Dr. David Tuller discusses the flaws of the PACE trial
https://www.youtube.com/watch?v=IGaUBE2 ... e=youtu.be
Ein offener Brief an Psychologische Medizin über "Erholung" und die PACE-Studie
13. März 2017
An open letter to Psychological Medicine about “recovery” and the PACE trial
13 March 2017
Dr. Robin Murray and Dr. Kenneth Kendler
Psychological Medicine
Cambridge University Press
University Printing House
Shaftesbury Road
Cambridge CB2 8BS
UK
Dear Dr. Murray and Dr. Kendler:
In 2013, Psychological Medicine published an article called “Recovery from chronic fatigue syndrome after treatments given in the PACE trial.”[1] In the paper, White et al. reported that graded exercise therapy (GET) and cognitive behavioural therapy (CBT) each led to recovery in 22% of patients, compared with only 7% in a comparison group. The two treatments, they concluded, offered patients “the best chance of recovery.”
PACE was the largest clinical trial ever conducted for chronic fatigue syndrome (also known as myalgic encephalomyelitis, or ME/CFS), with the first results published in The Lancet in 2011.[2] It was an open-label study with subjective primary outcomes, a design that requires strict vigilance to prevent the possibility of bias. Yet PACE suffered from major flaws that have raised serious concerns about the validity, reliability and integrity of the findings.[3] Despite these flaws, White et al.’s claims of recovery in Psychological Medicine have greatly impacted treatment, research, and public attitudes towards ME/CFS.
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http://www.virology.ws/2017/03/13/an-op ... ace-trial/
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