Montag, 13 Juli 2015
Formaldehyd in Einbalsamierungsflüssigkeit kann ALS Risiko für Bestattungsinstitut erheben.
Vorherige tierexperimentelle Forschung hat Verbindung zwischen chemischen und tödlich verlaufende Neurologische Krankheit gezeigt.
Formaldehyde in Embalming Fluid May Raise ALS Risk for Funeral Directors
Von Dennis Thompson
HealthDay Reporter
Montag, 13 Juli 2015 HealthDay News)--Männliche Bestattungsinstitut, die routinemäßig mit der Einbalsamierung Flüssigkeit erhöhtes Risiko der Entwicklung von Amyotrophe Lateralsklerose (ALS) sein könnte, findet eine neue Studie.
Diejenigen, deren Arbeitsplätze ...
Original
Formaldehyde in Embalming Fluid May Raise ALS Risk for Funeral Directors
Previous animal research has shown link between chemical and fatal neurological disease
Formaldehyde in Embalming Fluid May Raise ALS Risk for Funeral Directors
By Dennis Thompson
HealthDay Reporter
MONDAY, July 13, 2015 (HealthDay News) -- Male funeral directors who routinely work with embalming fluid might be at increased risk of developing amyotrophic lateral sclerosis (ALS), a new study finds.
Those whose jobs involved continual exposure to the formaldehyde in embalming fluid were three times more likely to develop the neurological disease, compared to people never exposed to the chemical, researchers reported in the July 13 issue of the Journal of Neurology Neurosurgery & Psychiatry.
The study found that the jobs ...
http://consumer.healthday.com/cognitive ... 01286.html
Google-Übersetzung
J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2015-310750
PostScript
Brief
Berufsbezogene Formaldehyd-Exposition und ALS Sterblichkeit in den USA
Pressemitteilung
Andrea L Roberts1,
Norman J Johnson2,
Verdienst E Cudkowicz3, 4,
Ki-Do-Eum5,
Marc G Weisskopf5, 6
...
Original
J Neurol Neurosurg Psychiatry doi:10.1136/jnnp-2015-310750
PostScript
Letter
Job-related formaldehyde exposure and ALS mortality in the USA
Press Release
Andrea L Roberts1,
Norman J Johnson2,
Merit E Cudkowicz3,4,
Ki-Do Eum5,
Marc G Weisskopf5,6
+
Author Affiliations
1Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
2United States Census Bureau, Washington DC, USA
3Harvard Medical School, Boston, Massachusetts, USA
4Department of Neurology, MGH MDA ALS Clinic, Massachusetts General Hospital, Boston, Massachusetts, USA
5Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Correspondence to
Dr Andrea L Roberts, Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Social and Behavioral Sciences, 677 Huntington Avenue, Boston, MA 02115, USA; ...
Received 3 March 2015
Revised 27 May 2015
Accepted 4 June 2015
Published Online First 13 July 2015
Animal models and in vitro experiments suggest neurotoxic effects of formaldehyde that may be relevant for amyotrophic lateral sclerosis (ALS). Formaldehyde induces neuronal τ protein misfolding and aggregation, leading to neuronal apoptosis. Formaldehyde also increases mitochondrial membrane permeability and causes oxidative damage partly by reducing superoxide dismutase activity, mechanisms implicated in ALS.
Studies have had mixed findings regarding formaldehyde exposure and ALS mortality. A large prospective study found an elevated risk that did not quite reach statistical significance, but found a strong dose–response relationship with total years of exposure.1 Two studies found no significant association,1 ,2 although one found a suggestion of elevated risk among the very highly exposed.2 We examine here the association of ALS mortality with job-related formaldehyde exposure in the National Longitudinal Mortality Study (NLMS), a US-representative cohort with occupation data collected prospectively.
Methods
The NLMS is a multistage probability sample of the civilian non-institutionalised population (response rate ∼96%). We included the 794 541 men and 674 694 women who were at ages 25+ when surveyed. Participants were asked about their current or most recent job. We used a formaldehyde exposure matrix constructed by industrial hygienists at the National Cancer Institute and previously described.3 Intensity and probability of formaldehyde exposure were calculated for each occupation and industry, and coded as none, low, medium or high.3 Intensity reflected the frequency and level of formaldehyde exposure; probability reflected the likelihood of any formaldehyde exposure.
NLMS records were matched to the National Death Index (NDI, 1979–2011) to obtain cause of death. ALS deaths were defined as International Classification of Diseases Ninth and 10th Edition (ICD)-9 335.2 …
http://jnnp.bmj.com/content/early/2015/ ... _top10_tab
