Haushaltschemikalien und Diabetes: eine überraschende Verbindung
2. Dezember 2016 | Andrew Smith
Eine neue Analyse zeigt, dass eine 25 % ige Reduktion der Exposition gegenüber bestimmten Haushaltschemikalien Diabetesfälle um ca. 13 % reduzieren würde – nicht so viel, wie eine ähnliche Reduktion Fettleibigkeit reduzieren würde, aber genug, um Milliarden von Dollar in jährlichen Gesundheit sparen Kosten.
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Original
Household Chemicals and Diabetes: A Surprising Link
Dec 02, 2016 | Andrew Smith
A new analysis indicates that a 25% reduction in exposure to certain household chemicals would reduce diabetes cases by approximately 13% — not as much as a similar reduction would reduce obesity rates, but enough to save billions of dollars in annual health costs.
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http://www.mdmag.com/medical-news/house ... ising-link
Die Studie
J Epidemiol Community Health doi:10.1136/jech-2016-208006
Short report
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
Open AccessPress Release
Leonardo Trasande1,2,3,4,
Erik Lampa5,
Lars Lind6,
P Monica Lind7
+
Author Affiliations
1New York University (NYU) School of Medicine, New York, New York, USA
2NYU Wagner School of Public Service, New York, New York, USA
3Department of Nutrition, NYU Steinhardt School of Culture, Education and Human Development, Food & Public Health, New York, New York, USA
4NYU College of Global Public Health, New York University, New York, New York, USA
5Uppsala Clinical Research Center, Uppsala, Sweden
6Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden
7Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
Correspondence to
Dr Leonardo Trasande, Department of Pediatrics, New York University School of Medicine, 403 East 34th Street, New York, NY 10016, USA; leonardo.trasande@nyumc.org
Received 27 June 2016
Revised 22 August 2016
Accepted 23 August 2016
Published Online First 27 October 2016
Abstract
Background A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diabetogenic exposures in the elderly in Europe.
Methods We leveraged the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (∼1000 participants), which has measured exposure to phthalates; dichlorodiphenyltrichloroethylene; polychlorinated biphenyls (PCBs) and perfluoroalkyl substances to examine their independent contribution to diabetes. We estimated risk reductions assuming identical 25% reductions across levels of 4 selected compounds (PCB 153, monoethylphthalate, dichlorodiphenyldichloroethylene and perfluorononanoic acid), and diabetes costs saved in European men and women if diabetogenic exposures are limited.
Results Reduction of chemical exposures was associated with a 13% (95% CI 2% to 22%) reduction in prevalent diabetes, compared with 40% resulting from an identical (25%) reduction in body mass index (BMI) in cross-sectional analyses. Extrapolating to Europe, 152 481 cases of diabetes in Europe and €4.51 billion/year in associated costs could be prevented, compared with 469 172 cases prevented by reducing BMI.
Conclusions These findings support regulatory and individual efforts to reduce chemical exposures to reduce the burden and costs of diabetes.
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http://jech.bmj.com/content/early/2016/ ... ull#ref-37
