Review
Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders
Elin Swedenborg*, Joëlle Rüegg*, Sari Mäkelä1 and Ingemar Pongratz
Department for Biosciences and Nutrition, Karolinska Institute at Novum, S-141 57 Huddinge, Sweden
1 Functional Foods Forum and Department of Biochemistry and Food Chemistry, University of Turku, FI-20014 Turku, Finland
(Correspondence should be addressed to J Rüegg; Email: joerue@ki.se)
* (These authors contributed equally to this work)
Endocrine disruption refers to the ability of chemicals to interfere with hormonal systems, and has raised considerable concern in recent years. Endocrine disruptive chemicals (EDCs) pose a documented risk to wildlife and have the potential to negatively influence human health. This review focuses on the molecular mechanisms of endocrine disruption and the possible involvement of EDCs in metabolic disorders. The first part describes the role of aryl hydrocarbon receptor (AhR) and nuclear receptors (NRs) in mediating effects of EDCs, in particular, how cross-talk between AhR and NR pathways can lead to endocrine disruption. The second part deals with how these receptors are involved in metabolic functions and how their targeting by EDCs can lead to disturbances in glucose and fat metabolism. The article illustrates that, although there is accumulating data on molecular mechanisms of EDC action as well as on EDC involvement in metabolic disorders, there is still a great demand for data that can unite the mechanistic and the toxicological/epidemiological observations.......
Baby Boomers: DDT Exposition verursacht Fettleibigkeit bis zu 3 Generationen später
Eine neue Studie veröffentlicht von der Abteilung für biologische Wissenschaften an der Washington State University (WSU) zeigt, dass die Exposition gegenüber dichlorodiphenyltrichloroethane (DDT) erhöhen können Fettleibigkeit bis zu 3 Generationen später erhöhen können.
DDT erfolgt durch das Phänomen der Krankheit-Vererbung (DIP), das zeigte sich als Forscher injizierten schwangere Ratten mit DDT injizierten. Es zeigte sich durch Beobachtung, dass die Nachkommen Probleme mit Übergewicht entwickelten.
Die Ur-Urenkel die geboren wurden, und nie DDT ausgesetzt waren, sie waren genetisch anfällig gegenüber höheren Fett und Gewichtszunahme.
Michael Skinner, Hauptautor und Professor an der WSU, sagte: "hier ist eine uralte Exposition bei Ihrer Urgroßmutter, die an Sie weitergegeben werden und du wirst an deine Enkelkinder weitergeben."
Baby Boomers: DDT Exposure Causes Obesity for 3 Generations
Susanne Posel
Occupy Corporatism
October 25, 2013
A new study released by the Department of biological sciences at Washington State University (WSU) shows that exposure to dichlorodiphenyltrichloroethane (DDT) can increase obesity rates up to 3 generations later.
DDT is effected by the disease inheritance phenomenon (DIP) was demonstrated when researchers injected pregnant rats with DDT. It was show through observation that the offspring developed issues with obesity.
By the great-great grandchildren were born, and having never been exposed to DDT, they were genetically prone toward higher levels of fat and weight gain.
Michael Skinner, lead author and professor at WSU, said: “Here is an ancestral exposure in your great-grandmother, which is passed on to you and you’re going to pass on to your grandchildren.” Skinner explained ...
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