von Amazone » Sonntag 30. Dezember 2007, 11:58
Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor and histamine in patients with self-reported multiple chemical sensitivity
Hajime KimataCorresponding Author Contact Information, E-mail The Corresponding Author
Department of Allergy, Ujitakeda Hospital, Uji-City, Kyoto Prefecture, Japan
Received 7 March 2003; revised 8 August 2003; accepted 10 August 2003. Available online 11 November 2004.
Abstract
Plasma levels of substance P, vasoactive intestinal peptide and nerve growth factor, but not histamine, were elevated in patients with self-reported multiple chemical sensitivity (sMCS). Exposure to volatile organic compounds (VOC) increased plasma levels of all parameters in these patients, while it had no effect in normal subjects or patients with atopic eczema/dermatitis syndrome (AEDS). Exposure to VOC also enhanced skin wheal responses induced by histamine in patients with sMCS, while it failed to do so in normal or AEDS subjects. These results indicate that exposure to VOC may enhance neurogenic inflammation with concomitant enhancement of histamine-induced responses.
Key words: Exposure to volatile organic compounds; neuropeptides; nerve growth factor; skin wheal response; self-reported multiple chemical sensitivity
Corresponding Author Contact InformationCorresponding author: Dr. Hajime Kimata, Department of Allergy, Ujitakeda Hospital, 24 – 1, Umonji, Uji, Uji-City, Kyoto Prefecture, 611-0021, Japan. Phone +81 774 25 2500, Fax: +81 774 25 2353