Biologische Definition MCS - Chemical Sensitivity

[Janik]

Wissenschaftler aus Italien, Schweden und Korea führten eine Multicenter Studie durch, um die biologische Definition von MCS - Chemical Sensitity darzulegen. Hier könnt Ihr den Volltext lesen.

Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes

Chiara De Luca a, Maria G. Scordo b, Eleonora Cesareo a, Saveria Pastore a, Serena Mariani a, Gianluca Maiani a,
Andrea Stancato a, Beatrice Loreti c, Giuseppe Valacchi d,e, Carla Lubrano c, Desanka Raskovic f,
Luigia De Padova c, Giuseppe Genovesi c, Liudmila G. Korkina a,⁎

a Laboratory of Tissue Engineering & Skin Pathophysiology, Dermatology Institute (IDI IRCCS), Rome, Italy
b Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala, Sweden
c Department of Medical Pathophysiology, University of Rome “La Sapienza”, Policlinico Umberto I, Rome, Italy
d Department of Biomedical Sciences, Siena University, Italy
e Department of Food and Nutrition, Keyung Hee University, Seoul, Korea
f 2nd Division of Dermatology, Dermatology Institute (IDI IRCCS), Rome, Italy

http://www.resolv.org/nationalconversation/comments/attachments/MCS%20Tested%20-ScienceDirect.pdf

[Amazone]

Für mich völlig unverständlich, warum die Autoren in einem anderen Beitrag von IEI sprechen:

Idiopathic environmental intolerances (IEI): From molecular epidemiology to molecular medicine

http://www.national-toxic-encephalopathy-foundation.org/iei.pdf

[Kira]

Der von Janik angegebene Link geht nicht mehr,
aber auf Pubmed findet man diese

Multicenter Studie
Biologische Definition der mehrfache chemische Empfindlichkeit von Redox-Zustand und Cytokine Profilerstellung und nicht von Polymorphismen Xenobiotikum-metabolisierenden Enzyme.

Toxicol Appl Pharmacol. 2010 Nov 1;248(3):285-92. doi: 10.1016/j.taap.2010.04.017. Epub 2010 Apr 27.

Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes.

De Luca C1, Scordo MG, Cesareo E, Pastore S, Mariani S, Maiani G, Stancato A, Loreti B, Valacchi G, Lubrano C, Raskovic D, De Padova L, Genovesi G, Korkina LG.


Abstract

BACKGROUND:

Multiple chemical sensitivity (MCS) is a poorly clinically and biologically defined environment-associated syndrome. Although dysfunctions of phase I/phase II metabolizing enzymes and redox imbalance have been hypothesized, corresponding genetic and metabolic parameters in MCS have not been systematically examined.

OBJECTIVES:

We sought for genetic, immunological, and metabolic markers in MCS.

METHODS:

We genotyped patients with diagnosis of MCS, suspected MCS and Italian healthy controls for allelic variants of cytochrome P450 isoforms (CYP2C9, CYP2C19, CYP2D6, and CYP3A5), UDP-glucuronosyl transferase (UGT1A1), and glutathione S-transferases (GSTP1, GSTM1, and GSTT1). Erythrocyte membrane fatty acids, antioxidant (catalase, superoxide dismutase (SOD)) and glutathione metabolizing (GST, glutathione peroxidase (Gpx)) enzymes, whole blood chemiluminescence, total antioxidant capacity, levels of nitrites/nitrates, glutathione, HNE-protein adducts, and a wide spectrum of cytokines in the plasma were determined.

RESULTS:

Allele and genotype frequencies of CYPs, UGT, GSTM, GSTT, and GSTP were similar in the Italian MCS patients and in the control populations. The activities of erythrocyte catalase and GST were lower, whereas Gpx was higher than normal. Both reduced and oxidised glutathione were decreased, whereas nitrites/nitrates were increased in the MCS groups. The MCS fatty acid profile was shifted to saturated compartment and IFNgamma, IL-8, IL-10, MCP-1, PDGFbb, and VEGF were increased.

CONCLUSIONS:

Altered redox and cytokine patterns suggest inhibition of expression/activity of metabolizing and antioxidant enzymes in MCS. Metabolic parameters indicating accelerated lipid oxidation, increased nitric oxide production and glutathione depletion in combination with increased plasma inflammatory cytokines should be considered in biological definition and diagnosis of MCS.

http://www.ncbi.nlm.nih.gov/pubmed/20430047