Isocyanate - Hauptauslöser berufsbedingtes Asthma

[Alex]

Berufsbedingtes Asthma wird hauptursächlich durch Isocyanate ausgelöst.
Ein Fallbericht aus Italien:

Isocyanates represent a leading cause of occupational asthma

Clin Toxicol (Phila). 2011 Jul;49(6):506-7.
Occupational exposure to toluene diisocyanate and neutrophilic bronchitis without asthma.
Pala G, Pignatti P, Moscato G.
Source

Allergy and Immunology Unit, Fondazione Salvatore Maugeri, Institute of Care and Research, Scientific Institute of Pavia, Pavia, Italy. giannipalass@libero.it

Isocyanates represent a leading cause of occupational asthma, and sputum neutrophilia or eosinophilia has been described in subjects with isocyanate-induced occupational asthma after exposure to these chemicals. One case of non-asthmatic eosinophilic bronchitis due to methylene diphenil isocyanates has been reported, but a similar condition in the instance of neutrophilic bronchial inflammation has never been described.
CASE DETAILS:

We report a 34-year-old woman, who, 18 months after beginning work in a plastic industry, reported the onset of dry cough at work. Spirometry was normal, reversibility and methacholine challenge tests were negative. A specific inhalation challenge with toluene diisocyanate elicited dry cough without significant changes in respiratory function. Sputum induction showed a post-challenge neutrophil increase.
DISCUSSION:

The results of our case suggest that the occurrence of a neutrophilic bronchial inflammation without the functional characteristics of occupational asthma as a consequence of exposure to toluene diisocyanate may also be considered, suggesting a diagnosis of occupational non-asthmatic neutrophilic bronchitis.

PMID: 21824062

http://www.ncbi.nlm.nih.gov/pubmed/21824062