Studie: Thiomersal in Impfung hirntoxische Wirkung

Studie: Thiomersal in Impfung hirntoxische Wirkung

Beitragvon mirijam » Freitag 15. Juni 2012, 12:58

Neue Studie über die toxischen Wirkungen von Qeucksilber aus Impfungen auf das Gehirn


Die Verabreichung von Thiomersal an jungen Ratten verursacht einen Anstieg von Glutamat und Aspartat im präfrontalen Kortex.

Da eine übermäßige Ansammlung von extrazellulärem Glutamat mit Exzitotoxizität verknüpft ist, implizieren die gewonnenen Daten, dass neonatale Exposition gegenüber Impfstoffen mit Thiomersal exzitotoxische Hirnverletzungen induziert, was zu Entwicklungsstörungen des Nervensystems führen könnte.

Die Studie:

„Neurochem Res. 2012 Feb;37(2):436-47. Epub 2011 Oct 21.

Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.

Duszczyk-Budhathoki M, Olczak M, Lehner M, Majewska MD.
SourceMarie Curie Chairs Program, Department of Pharmacology and Physiology of Nervous System, Institute of Psychiatry and Neurology, 02-957, Warsaw, Poland.

Abstract
Thimerosal, a mercury-containing vaccine preservative, is a suspected factor in the etiology of neurodevelopmental disorders. We previously showed that its administration to infant rats causes behavioral, neurochemical and neuropathological abnormalities similar to those present in autism. Here we examined, using microdialysis, the effect of thimerosal on extracellular levels of neuroactive amino acids in the rat prefrontal cortex (PFC). Thimerosal administration (4 injections, i.m., 240 μg Hg/kg on postnatal days 7, 9, 11, 15) induced lasting changes in amino acid overflow: an increase of glutamate and aspartate accompanied by a decrease of glycine and alanine; measured 10-14 weeks after the injections. Four injections of thimerosal at a dose of 12.5 μg Hg/kg did not alter glutamate and aspartate concentrations at microdialysis time (but based on thimerosal pharmacokinetics, could have been effective soon after its injection). Application of thimerosal to the PFC in perfusion fluid evoked a rapid increase of glutamate overflow. Coadministration of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS; 80 mg/kg; i.p.) prevented the thimerosal effect on glutamate and aspartate; the steroid alone had no influence on these amino acids. Coapplication of DHEAS with thimerosal in perfusion fluid also blocked the acute action of thimerosal on glutamate. In contrast, DHEAS alone reduced overflow of glycine and alanine, somewhat potentiating the thimerosal effect on these amino acids. Since excessive accumulation of extracellular glutamate is linked with excitotoxicity, our data imply that neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEAS may partially protect against mercurials-induced neurotoxicity.

PMID: 22015977 [PubMed - in process] PMCID: PMC3264864Free PMC Article"

Siehe hier:

http://www.ncbi.nlm.nih.gov/pubmed/22015977
mirijam
 

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