Amygdala-Schäden bei Affen durch Impfpungen

[mirijam]

Dramatische Änderung im Zentrum für Informationsverarbeitung & Gedächtnis durch "normales US-Impfprogramm"

Rhesus-Affen, die das normale Impfprogramm bekamen, hatten Schäden im Amygdala-Zentrum.

Diese interessante Studie zeigt, dass frühkindliche Impfungen bei Affen eine völlige Veränderung der Hirnentwicklung auslösen, und zwar in der Amygdala - einer wichtigen Hirnregion, die für Gedächtnis und Informations-Verarbeitung zuständig ist.



Die Studie

"Acta Neurobiol Exp (Wars). 2010;70(2):147-64.

Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study.

Hewitson L, Lopresti BJ, Stott C, Mason NS, Tomko J.
SourceDepartment of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. lch1@pitt.edu

Abstract
This longitudinal, case-control pilot study examined amygdala growth in rhesus macaque infants receiving the complete US childhood vaccine schedule (1994-1999). Longitudinal structural and functional neuroimaging was undertaken to examine central effects of the vaccine regimen on the developing brain. Vaccine-exposed and saline-injected control infants underwent MRI and PET imaging at approximately 4 and 6 months of age, representing two specific timeframes within the vaccination schedule. Volumetric analyses showed that exposed animals did not undergo the maturational changes over time in amygdala volume that was observed in unexposed animals. After controlling for left amygdala volume, the binding of the opioid antagonist [(11)C]diprenorphine (DPN) in exposed animals remained relatively constant over time, compared with unexposed animals, in which a significant decrease in [(11)C]DPN binding occurred. These results suggest that maturational changes in amygdala volume and the binding capacity of [(11)C]DPN in the amygdala was significantly altered in infant macaques receiving the vaccine schedule. The macaque infant is a relevant animal model in which to investigate specific environmental exposures and structural/functional neuroimaging during neurodevelopment.

Comment in
Acta Neurobiol Exp (Wars). 2011;71(1):178-9; author reply 180-1.

PMID: 20628439 [PubMed - indexed for MEDLINE] Free full text"


http://www.ncbi.nlm.nih.gov/pubmed/20628439#