Dänemark 2013 MCS-Studie Genexpression
Verfasst: Sonntag 9. Juni 2013, 10:13"Gene expression in individuals with MCS (2013 -)
One way to investigate the pathophysiological mechanisms in MCS is to use gene expression profiling. Gene expression profiling offers a reliable technique to obtain objective data, which can assist in clarifying disease mechanisms, and the technique is commonly used for both diagnostic purposes and in basic research.
So far no such studies have been conducted in MCS, but the technique has recently been utilized with success for detection of potential specific biomarkers in chronic fatigue syndrome. A similar approach can be employed in MCS research, where the selection of relevant genes will be based on current explanatory models for MCS, e.g. central sensitization.
Blood samples from MCS patients and controls will be collected at baseline, during and after a controlled chemical exposure in an exposure chamber. Additionally, to identify any physiological responses in the upper respiratory system as a result of the exposure, nasal epithelial lining fluid will be collected simultaneously to peripheral blood samples for quantification of inflammatory mediators in the upper airways. Supplementing physiological recordings such as galvanic skin response, heart rate and heart rate variability and respiration will also be measured.
The study will be initiated in March 2013 in collaboration with Umeå University, Sweden and the Danish Technical University."
http://www.mcsvidencenter.dk/?site=2&side=11&id=346
One way to investigate the pathophysiological mechanisms in MCS is to use gene expression profiling. Gene expression profiling offers a reliable technique to obtain objective data, which can assist in clarifying disease mechanisms, and the technique is commonly used for both diagnostic purposes and in basic research.
So far no such studies have been conducted in MCS, but the technique has recently been utilized with success for detection of potential specific biomarkers in chronic fatigue syndrome. A similar approach can be employed in MCS research, where the selection of relevant genes will be based on current explanatory models for MCS, e.g. central sensitization.
Blood samples from MCS patients and controls will be collected at baseline, during and after a controlled chemical exposure in an exposure chamber. Additionally, to identify any physiological responses in the upper respiratory system as a result of the exposure, nasal epithelial lining fluid will be collected simultaneously to peripheral blood samples for quantification of inflammatory mediators in the upper airways. Supplementing physiological recordings such as galvanic skin response, heart rate and heart rate variability and respiration will also be measured.
The study will be initiated in March 2013 in collaboration with Umeå University, Sweden and the Danish Technical University."
http://www.mcsvidencenter.dk/?site=2&side=11&id=346