MCS in Pubmed 2012

MCS in Pubmed 2012

Beitragvon Amazone » Montag 10. September 2012, 15:26

Adv Exp Med Biol. 2013;756:179-88.
Non-invasive Assessment of Exhaled Breath Pattern in Patients with Multiple Chemical Sensibility Disorder.
Mazzatenta A, Pokorski M, Cozzutto S, Barbieri P, Veratti V, Giulio CD.
Source
Sensorial Physiology Unit, Department of Neuroscience and Imaging, University of Chieti-Pescara \'G. d\'Annunzio\', Via dei Vestini 31, 66100, Chieti, Italy, amazzatenta@yahoo.com.
Abstract
Multiple chemical sensitivity (MCS) is a complex disorder initiated by chemical exposure, particularly through the airways. MCS patients report sensitivity or intolerance to low levels of a wide spectrum of chemicals. Symptoms could include asthma-like signs, rhinitis, fatigue, cognitive dysfunction, psycho-physiological alteration, and other specific tissue reactions resembling hypoxic and oxidative stress effects. To recognize physiological signs that would allow the diagnosis of MCS in a non-invasive way we investigated the potential application of a new sensor system. In healthy volunteers, we measured exhaled breath content in the control condition and under exposure to olfactory stressors that mimic hypoxic or pollutant stressors playing a potential role in the generation of the MCS disorder. The recording system used is based on metal oxide semiconductor (MOS) sensor having a sensing range of 450-2,000 ppm CO(2) equivalents, which is able to detect a broad range of compounds playing a potential role in the generation of the MCS disorder, while correlating directly with the CO(2) levels. The results indicate that the recording system employed was suitable for the analysis of exhaled breath content in humans. Interestingly, the system was able to detect and discriminate between the exhaled breath content taken from the control condition and those from conditions under stress that mimicked exposures to pollutant or hypoxia. The results suggest that chronic hypoxia could be involved in the MCS disorder.
PMID:
22836634
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22836634


Int J Hyg Environ Health. 2012 Apr 7. [Epub ahead of print]
Multiple chemical sensitivity: On the scent of central sensitization.
Tran MT, Arendt-Nielsen L, Kupers R, Elberling J.
Source
The Danish Research Centre for Chemical Sensitivities, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Denmark.

http://www.ncbi.nlm.nih.gov/pubmed/22487274
- Editiert von Thommy the Blogger am 10.09.2012, 20:34 -
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MCS in Pubmed 2012

Beitragvon Amazone » Montag 10. September 2012, 20:04

[quote]Adv Exp Med Biol. 2013;756:179-88.
Non-invasive Assessment of Exhaled Breath Pattern in Patients with Multiple Chemical Sensibility Disorder.
Mazzatenta A, Pokorski M, Cozzutto S, Barbieri P, Veratti V, Giulio CD.
Source
Sensorial Physiology Unit, Department of Neuroscience and Imaging, University of Chieti-Pescara 'G. d'Annunzio', Via dei Vestini 31, 66100, Chieti, Italy, amazzatenta@yahoo.com.
Abstract
Multiple chemical sensitivity (MCS) is a complex disorder initiated by chemical exposure, particularly through the airways. MCS patients report sensitivity or intolerance to low levels of a wide spectrum of chemicals. Symptoms could include asthma-like signs, rhinitis, fatigue, cognitive dysfunction, psycho-physiological alteration, and other specific tissue reactions resembling hypoxic and oxidative stress effects. To recognize physiological signs that would allow the diagnosis of MCS in a non-invasive way we investigated the potential application of a new sensor system. In healthy volunteers, we measured exhaled breath content in the control condition and under exposure to olfactory stressors that mimic hypoxic or pollutant stressors playing a potential role in the generation of the MCS disorder. The recording system used is based on metal oxide semiconductor (MOS) sensor having a sensing range of 450-2,000 ppm CO(2) equivalents, which is able to detect a broad range of compounds playing a potential role in the generation of the MCS disorder, while correlating directly with the CO(2) levels. The results indicate that the recording system employed was suitable for the analysis of exhaled breath content in humans. Interestingly, the system was able to detect and discriminate between the exhaled breath content taken from the control condition and those from conditions under stress that mimicked exposures to pollutant or hypoxia. The results suggest that chronic hypoxia could be involved in the MCS disorder.
PMID:
22836634
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22836634


Scientific articles
Multiple chemical sensitivity: On the scent of central sensitization.
Author:
Tran MT, Arendt-Nielsen L, Kupers R, Elberling J.

PubMed abstract
Journal:
Int J Hyg Environ Health
Year:
2012
Subject:
The central nervous system
The objectives of the study were to use quantitative sensory testing (QST) to study central hyperexcitability and multiple aspects of central sensory processing in MCS patients without comorbid overlapping disorders and to compare the results with those among matched controls.

The study included 15 MCS patients and 15 healthy matched controls. The following aspects of pain were assessed: capsaicin-induced secondary punctate hyperalgesia, stimulus response function to punctate mechanical stimuli before and after capsaicin injection, temporal summation to punctate stimuli post capsaicin injection, pressure pain thresholds, heat pain thresholds, tonic heat stimulation and conditioning pain modulation (CPM: formerly known as diffuse noxious inhibitory control or DNIC). 

The study demonstrated increased capsaicin-induced secondary punctate hyperalgesia in MCS patients without comorbid, overlapping disorders, suggesting facilitated central sensitization in MCS.
 
See also Holst H et al. 2011
http://www.mcsvidencenter.dk/?site=2&side=11&id=53&pub=31
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MCS in Pubmed 2012

Beitragvon Sternentaenzer » Mittwoch 12. September 2012, 05:21

Danke Amazone für diese guten Artikel!
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MCS in Pubmed 2012

Beitragvon Sternentaenzer » Mittwoch 12. September 2012, 10:03

Ein Sauerstoffmangel (Hypoxie) kann anscheinend den TRPV1 Rezeptor sensibilisieren:

http://www.ncbi.nlm.nih.gov/pubmed/21376466
Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC.
Ristoiu V, Shibasaki K, Uchida K, Zhou Y, Ton BH, Flonta ML, Tominaga M
Pain. 2011 Apr;152(4):936-45. Epub 2011 Mar 4.


[b]"...These data suggest that hypoxia is a new sensitization mechanism for TRPV1, which might be relevant to diabetes-related complications, and also for other diseases that are associated with acute hypoxia."[/b]
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MCS in Pubmed 2012

Beitragvon Sternentaenzer » Mittwoch 12. September 2012, 10:08

http://www.neurographics.org/2/2/1/4.shtml
Auf der Seite sind die Folgen von Sauerstoffmangel auf die Zelle an Hand von Bildern beschrieben. Leider ist sie auf Englisch.
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Re: MCS in Pubmed 2012

Beitragvon Twei » Samstag 23. November 2013, 16:36

Siehe auch fortführend:

MCS-Artikel in PUBMED - viewtopic.php?f=93&t=19308
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