Die schwedische Wissenschaftlerin Eva Millqvist hat wieder eine sehr aussagekräftige Studie veröffentlicht.
Hat jemand Zeit & Lust das Abstract für uns alle zu übersetzen?
Herzliche Grüsse
Silvia
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Relationship between self-reported odor intolerance and sensitivity
to inhaled capsaicin: proposed definition of airway sensory
hyperreactivity and estimation of its prevalence.
Johansson A, Millqvist E, Nordin S, Bende M.
Department of Otorhinolaryngology, Central Hospital, SE-541 85
Skovde, Sweden.
Chest. 2006 Jun;129(6):1623-8.
STUDY OBJECTIVES: The aim of this study was to investigate the
relationship between the behavioral consequences of self-reported
odor sensitivity with the chemical sensitivity scale for sensory
hyperreactivity (CSS-SHR) and cough sensitivity to inhaled
capsaicin. We also wanted to estimate the prevalence of airway
sensory hyperreactivity (SHR), which was defined as a positive CSS-
SHR score in combination with a positive capsaicin inhalation test
result.
DESIGN: A general population-based study with randomly selected
individuals after stratification for age and gender.
SETTING: Skovde Central Hospital, Departments of Lung Medicine and
Otorhinolaryngology, Sweden.
PARTICIPANTS: A total of 693 randomly selected individuals from a
population-based study in which 595 persons (86%) responded to the
CSS-SHR questionnaire.
INTERVENTIONS: The individuals were divided into four groups with
different odor sensitivity according to their CSS-SHR score. Of
these, 137 individuals were randomly recruited for the capsaicin
inhalation test. Capsaicin inhalation was performed with
concentrations of 0.4 and 2.0 mumol/L in a randomized order. The
number of coughs were registered and counted for 10 min from the
start of each inhalation.
MEASUREMENTS AND RESULTS: Of the 137 individuals who were recruited
for the capsaicin inhalation test, 103 (75%) participated. Sixteen
individuals had increased cough sensitivity and fulfilled the
criteria for a positive capsaicin inhalation test result. Of the
individuals with a positive capsaicin inhalation test result, > 80%
also had a positive CSS-SHR score. Only 5% of the individuals with a
negative CSS-SHR score had a positive capsaicin inhalation test
result. The order of inhaled capsaicin concentration was found to
influence the results. The prevalence of SHR with the definition
given above was estimated to be 6.3% in this general population.
CONCLUSIONS: A high CSS-SHR score was found to be directly related
to the sensitivity for inhaled capsaicin, which made it possible to
relate subjective data to objective findings.
PMID: 16778284 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?
db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16778284&query_hl=
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